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Hair Loss Treatment
- Capciacin effects on hair follicles
Neurosci Lett. 1987;74(2):139
Classification of aberrant primary afferents in the substantia gelatinosa of the rat following neonatal capsaicin treatment.
Beal JA, Knight DS.
Administration of capsaicin to newborn rats results in a loss of a large percentage of primary afferent C fibers many of which terminate in the substantia gelatinosa (SG). Using the Golgi silver impregnation technique, the present study shows that the loss of C fibers results in an invasion of aberrant myelinated primary afferents in the SG by 10 days after birth. The aberrant afferents, identified on the basis of their distinctive collateral arborizations, are derived from hair follicles and slowly adapting type I mechanoreceptors.
- Hair loss due to alopecia areata
J Invest Dermatol. 1985 Dec;85(6):569-72.Links
Expression of HLA-DR by anagen hair follicles in hair loss due to alopecia areata.Messenger AG, Bleehen SS.
The expression of HLA-DR within hair follicles in hair loss secondary to alopecia areata was studied using an immunoperoxidase method. Scalp biopsies were taken from 12 patients with hair loss due to alopecia areata and from 6 normal control subjects. Frozen sections were stained with a panel of 4 anti-HLA-DR monoclonal antibodies, Leu 2, Leu 3, Leu 4, and T6 antibodies. The expression of DR in normal hair follicles and in most anagen follicles from nonlesional alopecia skin was confined to dendritic cells which were sparse below the level of the arrector pilorum insertion. ..snip... The aberrant expression of DR antigens by hair follicle epithelium provides direct evidence that immune mechanisms are operating in the pathogenesis of alopecia areata- induced hair loss. In a previous study of alopecia areata we found evidence of cell injury confined to the precortical matrix and presumptive cortex in lesional anagen follicles. The relative restriction of epithelial DR expression to the same site suggests that this region of the follicle is of fundamental importance in the disease process.
- Hair Loss Treatment Blog
Hair Loss Treatment Blog
- Hormones in Hair loss in women
Int J Dermatol. 1992;31(12):858
Hormonal status in postmenopausal androgenetic alopecia.
Georgala S, et al
edited for blog
Androgenetic alopecia or pattern hair loss is thought to be caused by increased androgen action on hair follicles with menopause. Testosterone, estradiol and sex hormone binding globulin (SHBG) serum levels were determined in ten postmenopausal women with pattern hair loss and in ten sex and age matched healthy controls. No statistically significant differences were found in the hormone levels between the patients and the controls. These findings suggest that a genetically determined functional alteration of androgen receptors and/or a metabolic disturbance may exist in the hair follicle keratinocytes in pattern hair loss.
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