Hair Loss Blog

Treatment of thinning eyelash hair

07/20/10

01:49:45 pm, by peterpro

, 234 words, 13 views

Categories: Announcements [A]

Treatment of thinning eyelash hair

Clin Ophthalmol. 2010 Apr 26;4:349-58.

Bimatoprost in the treatment of eyelash hypotrichosis.

Law SK.

edited for hai rloss treatment blog

Eyelashes hypotrichosis is a condition indicated by an inadequate amount of
eyelashes. Hypertrichosis of eyelashes, characterized by excessive eyelash
growth, is a regular phenomenon associated with ophthalmic prostaglandin and
prostamide analogs. Recently, the US Food and Drug Administration approved
Latisse((R)) (bimatoprost 0.03% solution), identical to the ophthalmic solution
for glaucoma treatment, for increasing eyelash length, thickness and darkness in
patients with hypotrichosis of the eyelashes. When prostaglandin and prostamide
analogs interact with the prostanoid receptors in the hair follicle, this most
likely stimulates the resting follicles (telogen phase) to growing follicles
(anagen phase). Prostaglandin and prostamide analogs may also prolong the anagen
phase of eyelashes, leading to an increase of eyelash length. Although
bimatoprost is effective in promoting increased growth of healthy eyelashes and
adnexal hairs, its effectiveness in patients with eyelash with hai rloss due to alopecia areata is debatable and its protective effect is not yet studied in patients with eyelash
loss secondary to radiation or chemotherapy. Bimatoprost is generally safe when
applied to the base of the eyelashes at the lid margin with minimum side effects.
However, other ocular or systemic side effects associated with ophthalmic
prostaglandin and prostamide analogs may occur when instilled on the surface of
the eye, and patients must be informed and monitored.

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Capciacin effects on hair follicles
Neurosci Lett. 1987;74(2):139

Classification of aberrant primary afferents in the substantia gelatinosa of the rat following neonatal capsaicin treatment.

Beal JA, Knight DS.

Administration of capsaicin to newborn rats results in a loss of a large percentage of primary afferent C fibers many of which terminate in the substantia gelatinosa (SG). Using the Golgi silver impregnation technique, the present study shows that the loss of C fibers results in an invasion of aberrant myelinated primary afferents in the SG by 10 days after birth. The aberrant afferents, identified on the basis of their distinctive collateral arborizations, are derived from hair follicles and slowly adapting type I mechanoreceptors.
Hair loss due to alopecia areata
J Invest Dermatol. 1985 Dec;85(6):569-72.Links
Expression of HLA-DR by anagen hair follicles in hair loss due to alopecia areata.

Messenger AG, Bleehen SS.

The expression of HLA-DR within hair follicles in hair loss secondary to alopecia areata was studied using an immunoperoxidase method. Scalp biopsies were taken from 12 patients with hair loss due to alopecia areata and from 6 normal control subjects. Frozen sections were stained with a panel of 4 anti-HLA-DR monoclonal antibodies, Leu 2, Leu 3, Leu 4, and T6 antibodies. The expression of DR in normal hair follicles and in most anagen follicles from nonlesional alopecia skin was confined to dendritic cells which were sparse below the level of the arrector pilorum insertion. ..snip... The aberrant expression of DR antigens by hair follicle epithelium provides direct evidence that immune mechanisms are operating in the pathogenesis of alopecia areata- induced hair loss. In a previous study of alopecia areata we found evidence of cell injury confined to the precortical matrix and presumptive cortex in lesional anagen follicles. The relative restriction of epithelial DR expression to the same site suggests that this region of the follicle is of fundamental importance in the disease process.
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Hormones in Hair loss in women
Int J Dermatol. 1992;31(12):858

Hormonal status in postmenopausal androgenetic alopecia.

Georgala S, et al

edited for blog

Androgenetic alopecia or pattern hair loss is thought to be caused by increased androgen action on hair follicles with menopause. Testosterone, estradiol and sex hormone binding globulin (SHBG) serum levels were determined in ten postmenopausal women with pattern hair loss and in ten sex and age matched healthy controls. No statistically significant differences were found in the hormone levels between the patients and the controls. These findings suggest that a genetically determined functional alteration of androgen receptors and/or a metabolic disturbance may exist in the hair follicle keratinocytes in pattern hair loss.